2013年11月12日星期二
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alcohol and anxiety Symptoms mean and What you should do nexta brain protein
linked to emotion and fear may explain why some people who suffer high levels of
anxiety may be at greater risk of alcoholism, a study has found.The research
could help in the development of treatments for both anxiety and
alcoholism.Scientists at the university of illinois at chicago(Uic)Found that
rats selectively bred to have a preference for alcohol(P rats), had higher
anxiety levels and consumed more alcohol than rats that had no preference for
alcohol(Np rats).Tests also showed that the alcohol loving p rats displayed
lower levels of a protein, called creb, in parts of the brain associated with
emotion, fear and anxiety, compared with their teetotal np cousins.One function
of the creb protein is to regulate the brain's production of a molecule that
regulates anxiety and alcoholdrinking behaviours.For the p rats, alcohol
consumption eased anxiety and increased creb levels.But alcohol did not have a
similar effect on the temperate rats.The findings are intriguing, according to
dr tingkai li, director of the national institute on alcohol abuse and
alcoholism which supported the research. "These experiments help us address
questions about the potential role that anxiety might play in human alcoholism",
he said.Rats' anxiety levels were measured with a piece of apparatus consisting
of two open arms and two closed arms connected to a central platform.Rats who
spend more time in the closed arms were judged to be more anxious.The
researchers showed that chemically stimulating creb activity in the parts of the
brain associated with anxiety could decrease the anxiety and alcohol intake in p
rats.And chemically blocking creb prompted np rats to display anxious behaviour
and turn to alcohol.Lead researcher subhash pandey said that the p rats appear
to selfmedicate with alcohol to alleviate anxiety, a behaviour often seen in
humans.The research suggests a deficit of the creb brain protein in people who
are genetically predisposed to anxiety and alcohol drinking behaviours, he said.
"This is the first direct evidence that a hereditary deficiency of creb protein
is associated with high anxiety and alcoholdrinking behaviours,"Said dr pandey,
who is director of neuroscience alcoholism research at the uic college of
medicine.Results of the study are published in this month's issue of the journal
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